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**The Image Adjustment Layers**
Image adjustments are accomplished by adjusting the brightness and contrast of individual pixels or editing the overall brightness/contrast of the image as a whole. The image adjustments are represented as _layers_, which are a set of images in a stacked file. You can place image adjustments in layers to keep them separate and keep track of how they affect your image. When you make adjustments to an image, the adjustments you make are made in a specific layer. If you need to return the image to its original appearance, you simply delete that layer (refer to Figure 1-4).
The image adjustments in the following exercise are the very same adjustments you performed in the Digital Photo Frame project shown in Figure 1-1.
**Figure 1-4** Right-click and choose Layer Settings to access the adjustment layers in Photoshop.
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Did you know that Photoshop Elements can be used to improve your work? Below we have compiled a list of free Photoshop Elements tutorials and guides to help you improve your work, learn a little more about your software and get a better understanding of your work.
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In 2012, 11 months after the commercial-grade batteries in the iPad first got a discharge warning, Apple publicly complained about all the premature replacements. These days, the warning appears after only about a year of normal use. The number of batteries replaced in a given 12-month period has since dropped to 1.5 per 1,000 units, down from 4.7 per 1,000 units last year. Apple’s own health-tracking software now warns users when their battery life is starting to decline.
Battery-life is a kind of gadget self-discipline.
For a consumer, battery life is a kind of gadget self-discipline. The more you use a device, the less it lasts. That’s true for your cellphone, laptop, all-day digital camera, tablet, and every other kind of gadget you own.
Apple makes a big deal of its own longevity. Its marketing materials brag about the company’s 94 percent return rate, over 30 years. “Apple engineers have been working hard to make sure that the batteries last as long as possible,” they claim. “If our tracking data is any indication, over time, this increased battery life will mean that our users will use their iPhone less and less.”
But what’s worth noting is that Apple’s survival rate is really the better measure of its longevity. Rather than merely counting the percentage of devices that remain functional after a given number of years, life expectancy is defined by the percentage of devices that are ever repaired or replaced at all.
Last year, for example, Apple’s computing devices collectively experienced a replacement rate of 2.8 per 1,000. That’s worse than the average phone, which experiences a replacement rate of 2.1 per 1,000. Only a couple of computers per 1,000 ever experience a hardware failure.
Three years ago, Apple’s median life expectancy was 2.5 per 1,000, or roughly what you might expect if half of devices were getting repaired each year. Since then, the median has risen to 2.9 per 1,000, and if Apple’s own marketing claims were to be believed, it’s now almost at its design goal of 3.0.
Before the publicity-shy CEO takes this one last victory lap, however, let’s talk about the standard caveats. People don’t replace
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Metabolism of 1-beta-D-arabinofuranosylcytosine and 1-beta-D-arabinofuranosyluracil in mouse cell lines.
The metabolic fate of 1-beta-D-arabinofuranosylcytosine (araC) and 1-beta-D-arabinofuranosyluracil (araU) has been determined for the mouse leukemia cell lines P388-D1 and L1210. The metabolism of these compounds has been studied by comparison of the growth rate of these cell lines in the presence and absence of drug. The araU was found to inhibit DNA synthesis in both cell lines at a dose of 7.5 to 30 micrograms/mL. In addition, araC caused a reduction in araU incorporation into cellular DNA in P388-D1 cells. AraU incorporation into DNA was reduced to 20% of control values at a drug concentration of 25 micrograms/mL in P388-D1 cells and 35% in L1210 cells. AraC incorporation into DNA at a drug concentration of 50 micrograms/mL was reduced to 26% of control values in P388-D1 cells and 6% in L1210 cells. In the absence of araC and araU, incorporation into DNA was 70 and 105% of control in P388-D1 and L1210 cells, respectively. The results indicate that in both cell lines araC was metabolized to araU, which was in turn incorporated into DNA. In addition, araU was the major product of araC metabolism in both cell lines. In both cell lines, 30 to 40% of the remaining araU was phosphorylated to araU monophosphate, and in P388-D1 cells, 5% was subsequently phosphorylated to araC.—
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lang: en
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