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Oxytocin injection is the standard treatment for postpartum haemorrhage, but a major side effect is uterine hyperstimulation. The aim of this study was to compare the effectiveness of oral and nasal oxytocin for management of postpartum haemorrhage. In a prospective, randomized, controlled study, a consecutive sample of 88 women undergoing vaginal delivery were assigned to receive oral or nasal oxytocin via a bulb syringe. The primary outcome was reduction in postpartum haemorrhage and the secondary outcome was initial treatment failure. Compared with oral oxytocin, nasal oxytocin resulted in a greater initial treatment failure rate and a longer time to treatment failure. The effect of oxytocin was similar in both groups. Adverse effects did not differ between groups. Oral and nasal oxytocin have similar effectiveness for initial management of postpartum haemorrhage. Oral oxytocin does not achieve lower initial treatment failure rates and additional treatment may be required to control haemorrhage.Facial Effortless Female Facelift
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J. Membrane Biol. 161:1-12, 2002; and Skerra et al., Nature 389:737-741, 1997). However, the development of a ligand-mediated endocytosis mechanism leading to delivery of encapsulated cargo to a cytosolic compartment has been elusive.
A number of strategies have been investigated to achieve a ligand-mediated internalization of non-antigenic molecules, small molecules or particles. These include either the use of specific ligands on the particle surface (e.g., transferrin-modified liposomes), covalent or non-covalent interactions with ligands present on the cell surface, or receptors (e.g., receptor mediated endocytosis), or the use of physicochemical properties such as particle size and zeta potential (ZP) (see for example: Matthews et al., Eur. J. Biochem. 179:379-384, 1989; and Shields et al., J. Controlled Release 11:149-163, 1988). Other research has identified cell lines that are either naturally receptor-mediated or inducibly overexpressing receptor-mediated endocytosis. These lines include, for example, L-cells (Mouse L-cell line) and A549 cells (Human